The 19-year-old has taken glory in three of the last four nights to move ahead of Jonny Clayton at the top of the table, and his performance in Berlin last week was arguably his most impressive of the tournament so far.
The Nuke maintained at least a 105 average in victories against Stephen Bunting, Gerwyn Price, and Michael van Gerwen, while posting at least 40 per cent on the checkouts, making it near impossible for anyone to beat him.
Littler even produced not one, but two eye-catching 170 checkouts in the final, including one in the decisive leg, to secure an incredible 6-4 victory against Van Gerwen and a third £10,000 nightly prize of 2026.
It's difficult to imagine anyone stopping the reigning world champion if he's in the same mood on Thursday, and the teenager has a more than ideal start to the night.
Littler in a league of his own
A quarter-final showdown against Gian van Veen awaits the 2024 Premier League champion, and this has the makings of another dominant Littler display.
Van Veen missed night seven in Dublin after suffering from kidney stones, and the Dutchman arguably returned to action prematurely in Berlin as treatment left him feeling tired and fatigued.
As a result, the 23-year-old struggled to find his usual rhythm on stage, and despite battling bravely, he was ultimately outclassed by Price in a 6-1 defeat.
It's anyone's guess as to whether the world No. 3 is 100 per cent fit, but regardless of his current health, Van Veen has found Littler a thorn in his side in recent months. The Nuke has won four of their last five meetings, and all have been by a comfortable margin.
In front of the Mancunian crowd, Littler will be even more fuelled to continue his winning streak, and the statistics highlight his recent dominance in the competition. Over the past three weeks, the world No. 1 has recorded the highest average (103.90), the most 180s (35, 16 ahead of Price in second), and the best double percentage (46.53 per cent).
All of those metrics prove he's in a league of his own, and as we enter the second half of the Premier League campaign, the Warrington-born star is threatening to run away with top spot.
Littler 'surprised' about Humphries
While no one is shocked about Littler sitting two points clear of Clayton at the top, there is an element of surprise that Humphries occupies a place outside the play-offs.
Two points adrift of fourth-place Van Gerwen following his 6-3 defeat against the Dutchman in Berlin, Cool Hand has ground to make up in pursuit of Finals Night.
Speaking in his pre-Manchester press conference on Wednesday afternoon, Littler admits he's 'surprised' about the position the world No. 2 is in, but backs him to put things right.
"Yeah, it definitely surprises me, obviously everyone goes on about Luke and Luke, but it's very different for him," Littler said.
"But yeah, that's his worry, and he's got to get on the practice board and make things right. Still a long way to go, and it wouldn't surprise me if he came through to the top four and went to the O2."
Poor finishing is the underlying reason why Humphries isn't duelling with Littler at the top, with only Rock recording a lower checkout percentage than the 31-year-old so far (34.86 per cent).
On the other hand, only Littler (102.25) has averaged higher than Humphries (100.47) throughout the tournament, so if he can start converting his chances at double regularly, we could see a Luke versus Luke final in Manchester for the first time in this year's Premier League.