The marquee game did not disappoint with Manchester City landing a key blow in the title race with a 2-1 win over Arsenal, narrowing the gap to the leaders down to three points.
Elsewhere, Liverpool scored late to win the first Merseyside derby at Everton's new stadium 2-1, Aston Villa won a thriller 4-3 against Sunderland and Leeds and Nottingham Forest earned victories to pull away from the relegation zone.
Goalkeeper
Bernd Leno (Fulham) - 7.6
Fulham's 0-0 draw at Brentford lacked real quality for large portions of the match, but Leno still had to be sharp when needed.
The German made four saves for the Cottagers, which included one of the stops of the season as he showed fast reflexes to deny Dango Ouattara in the 90th minute.
Defenders
James Justin (Leeds) - 9.1
Justin put together a top performance both in defence and going forward in Leeds' 3-0 win over Burnley.
He won nine duels, four tackles and made six clearances after scoring a superb acrobatic effort to open the scoring.
Ibrahima Konate (Liverpool) - 8.3
Konate had to stay concentrated for Liverpool as they downed bitter rivals Everton late on.
The Frenchman looked solid at the back, winning nine duels, all three tackles and making seven clearances.
Jaydee Canvot (Crystal Palace) - 8.5
Young Crystal Palace star Canvot put together one of his best defensive displays in the Eagles' subdued 0-0 draw with West Ham.
The 19-year-old made a game-high 11 clearances, won eight duels and boasted a passing accuracy of 92%.
Midfielders
Marcus Tavernier (Bournemouth) - 8.4
An energetic Tavernier epitomised Bournemouth's season as he inspired their 2-1 win at Newcastle.
The former Newcastle academy player opened the scoring by tapping in from close range.
Morgan Gibbs-White (Nottingham Forest) - 9.1
Gibbs-White has stepped up in Forest's hour of need and he more than did his bit with a 15-minute hat-trick in a 4-1 rout of Burnley.
Two clinical strikes and a well-placed header clawed Forest into the lead after they were trailing, which eventually helped them pull five points clear of the drop.
Bruno Fernandes (Manchester United) - 8.2
United's assist machine Fernandes appears to be storming his way towards the Premier League record as he notched his 18th of the season in their 1-0 win at Chelsea.
The Portuguese's cross was dispatched by Matheus Cunha, meaning he needs just two more assists to match the mark of 20 set by Thierry Henry and Kevin De Bruyne.
Rayan Cherki (Manchester City) - 8.4
Cherki looked at his silky best for City against Arsenal with a series of deft touches, dribbles and a wonderful individual goal.
The tricky Frenchman weaved his way into the penalty area, evading a couple of challenges before slotting into the corner to give City a precious lead in the high-stakes title clash.
Morgan Rogers (Aston Villa) - 8.2
Villa star Rogers had his say in what turned out to be a high-scoring, eventual win at home to Sunderland.
Rogers picked up possession in the box and tucked away his shot via the foot of the post with his weaker left foot.
Forwards
Ollie Watkins (Aston Villa) - 9.2
Hitting a vein of scoring form, Watkins more than made his mark as he netted twice and also notched an assist in Villa's victory.
The England striker took four shots, had eight touches in the box and created two big chances as he recorded a 9.2 Flashscore player rating, the highest score of the week.
Xavi Simons (Tottenham) - 8.1
Dutch star Simons gave everything for Tottenham and scored a beautiful curling effort in their 2-2 draw with Brighton.
The 23-year-old took four shots, created one big chance and drew four fouls for Spurs, who were denied at the death and still remain in the relegation zone.