One positive piece of news for Pep Guardiola is the potential return to fitness for John Stones, who could feature in their match with West Ham on Saturday.
Elsewhere, the AFCON exodus bites across the board, but nowhere is it felt more so than at Sunderland, who are without a whopping six first-team players for the foreseeable future.
Check out who's missing through injury or suspension ahead of the next round of Premier League fixtures:
Newcastle v Chelsea
WON'T PLAY
Botman S. | Lower back injury
Burn D. | Chest injury
Krafth E. | Knee injury
Livramento V. | Knee injury
Osula W. | Ankle injury
Trippier K. | Hamstring injury
Colwill L. | Knee injury
Delap L. | Shoulder injury
Essugo D. | Thigh injury
Estevao | Muscle injury
Lavia R. | Thigh injury
Mudryk M. | Suspended
DOUBTFUL
Pope N. | Muscle injury
Bournemouth v Burnley
WON'T PLAY
Adams T. | Knee injury
Akinmboni M. | Muscle injury
Christie R. | Knee injury
Doak B. | Hamstring injury
Milosavljevic V. | Knee injury
Amdouni Z. | Knee injury
Beyer J. | Hamstring injury
Foster L. | International duty
Humphreys B. | Lacking match fitness
Mejbri H. | Suspended
Roberts C. | Groin injury
Tuanzebe A. | International duty
Brighton v Sunderland
WON'T PLAY
Baleba C. | International duty
Dunk L. | Yellow cards
Gomez D. | Yellow cards
March S. | Knee injury
Tzimas S. | Knee injury
Webster A. | Knee injury
Alese A. | Shoulder injury
Diarra H. | International duty
Mandava R. | International duty
Masuaku A. | International duty
O'Nien L. | Red card
Sadiki N. | International duty
Talbi C. | International duty
Traore B. | International duty
Manchester City v West Ham
WON'T PLAY
Bobb O. | Hamstring injury
Doku J. | Leg injury
Kovacic M. | Heel injury
Marmoush O. | International duty
Rodri | Thigh injury
Diouf M. | International duty
Fabianski L. | Back injury
Wan-Bissaka A. | International duty
DOUBTFUL
Stones J. | Thigh injury
Wolves v Brentford
WON'T PLAY
Agbadou E. | International duty
Bellegarde J. | Muscle injury
Bentley D. | Ankle injury
Chirewa T. | International duty
Chiwome L. | Knee injury
Gomes R. | Groin injury
Mosquera Y. | Yellow cards
Munetsi M. | Calf injury
Carvalho F. | Knee injury
Dasilva J. | Knee injury
Milambo A. | Knee injury
Onyeka F. | International duty
Ouattara Da. | International duty
DOUBTFUL
Nelson R. | Knock
Tottenham v Liverpool
WON'T PLAY
Bissouma Y. | International duty
Dragusin R. | Knee injury
Kulusevski D. | Knee injury
Maddison J. | Knee injury
Sarr P. M. | International duty
Solanke D. | Ankle injury
Takai K. | Foot injury
Udogie D. | Muscle injury
Bajcetic S. | Hamstring injury
Chambers L. | Back injury
Endo W. | Ankle injury
Gakpo C. | Injury
Gomez J. | Injury
Leoni G. | Knee injury
Salah M. | International duty
Scanlon C. | Hamstring injury
Everton v Arsenal
WON'T PLAY
Branthwaite J. | Hamstring injury
Coleman S. | Hamstring injury
Gueye I. | International duty
Ndiaye I. | International duty
Rohl M. | Groin injury
Dowman M. | Ankle injury
Gabriel | Muscle injury
Havertz K. | Knee injury
Mosquera C. | Ankle injury
White B. | Injury
DOUBTFUL
Dewsbury-Hall K. | Hamstring injury
Grealish J. | Thigh injury
Leeds v Crystal Palace
WON'T PLAY
James D. | Hamstring injury
Longstaff S. | Calf injury
Nmecha L. | Thigh injury
Cardines R. | Muscle injury
Doucoure C. | Knee injury
Kamada D. | Hamstring injury
Kporha C. | Back injury
Munoz D. | Knee injury
Riad C. | Knee injury
Sarr I. | International duty
Aston Villa v Manchester United
WON'T PLAY
Barkley R. | Knee injury
Mings T. | Hamstring injury
Sancho J. | Loan agreement
Casemiro | Yellow cards
de Ligt M. | Back injury
Diallo A. | International duty
Maguire H. | Hamstring injury
Mazraoui N. | International duty
Mbeumo B. | International duty
DOUBTFUL
Martinez E. | Back injury
Torres P. | Calf injury
Fulham v Nottingham Forest
WON'T PLAY
TBD
TBD