Another win - it would be their sixth in succession during qualifying - would give them 18 points, and with nearest chasers Albania only able to get a maximum of 17 points, the Three Lions could therefore experiment in the final two qualifiers that take place in November.
Mindset key for Latvia clash
That has to be the mindset for Thomas Tuchel and Co., rather than coast now and make life a little more difficult for themselves.
Even though England haven't always been at their most dynamic in this qualifying campaign, the win in Serbia showed the football world exactly what the squad is capable of when they're on song.
Back in March, the Tuchel era began with a 2-0 win over Albania, quickly followed by a 3-0 victory over Latvia at Wembley.
On that occasion, Reece James, Harry Kane and Eberechi Eze were all on target for the hosts, though none of that trio played any part in England's most recent fixture, the 3-0 friendly win over Wales.
Tuchel does have the luxury of some decent strength in depth these days, so if there are any concerns over players with niggling injuries, keeping them sidelined for a little longer is now an option open to the German.
Kane set to return
Were Kane to be risked in Tuesday's fixture - and it appears he has overcome his recent injury trouble - he will have the chance to extend his England scoring record, which stands at an incredible 74 goals in 109 appearances, some 21 more than nearest rival, Wayne Rooney, whose 53 goals came in 120 international appearances.
Tuesday's game is only the second-ever meeting between England and Latvia, and the latter's only win in the group to date came against whipping boys, Andorra.
They have, however, managed to get draws against Andorra and Albania, and the only game in which they were defeated at home in qualifying came via a narrow 1-0 victory for the Serbians.
England remain the only team in the five-nation UEFA qualifying groups still to have not conceded a goal during this qualification cycle, scoring 13 themselves, so the hosts will understand how much of a tall order it will be for them to get anything out of the match, even if the visitors aren't firing on all cylinders.
Latvia have a mountain to climb
To give the size of their task even more context, Latvia have won just one of their last 12 matches over the past year, and their record when playing against nations that are in the top 10 is 14 losses from 14 games, one goal scored, and 41 conceded.
During the Wembley game in March, the Latvians managed just one shot on target against England's eight, and just three total attempts compared to 27 from the Three Lions. Thomas Tuchel's side also dominated possession, having 73.4% of the ball across the 90 minutes.
On that basis, it won't be a surprise to see the Wolves begin the match with an overly defensive 5-4-1 set-up.
Although that will invite England onto them, given the hosts' attacks are only likely to be sporadic at best, by packing the back line, it could make life that little bit more difficult for the Three Lions.
Bukayo Saka's return from injury couldn't have come at a better time, and his creativity and verve down England's right-hand side will be key in opening up the passing lanes against what's expected to be a stubborn response from Paolo Nicolato's side.
Can England continue perfect qualifying campaign?
They will be missing their own star man, captain Kristers Tobers, after he picked up a nasty injury at the end of September, though that shouldn't affect the way in which Nicolato sets his stall out.
It's difficult to look beyond another England victory, and even if one considers that Tuchel's team weren't particularly impressive in their games against Andorra when they should've really scored a hatful, the fact remains that they were able to get over the line and nab all three points.
Even if a goal (or goals) don't arrive until later in the game, as long as England emerge with more goals than their hosts, the history books will show a perfect campaign - to this point at least - and qualification to their seventh successive World Cup finals.
When one also considers that there was genuine concern at what might happen once Gareth Southgate had tendered his resignation, Tuchel will have answered his critics in the best possible way should England qualify without even conceding a goal.
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